HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophene-3-boronic acid → (1H-Indol-5-yl)-(6-thiophen-3-yl-thieno[3,2-d]pyrimidin-4-yl)-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophene-3-boronic acid | HCID 581760 | — |
| Reactant | (6-Bromo-thieno[3,2-d]pyrimidin-4-yl)-(1H-indol-5-yl)-amine | HCID 18383051 | — |
| Product | (1H-Indol-5-yl)-(6-thiophen-3-yl-thieno[3,2-d]pyrimidin-4-yl)-amine | HCID 18383059 | — |
Reaction Steps
The title compound was prepared from thiophene-3-boronic acid and (6-bromo-thieno[3,2-d]pyrimidin-4-yl)-(1H-indol-5-yl)-amine by a procedure analogous to example 2. 1H NMR (400 MHz, DMSO) d 11.4 (s, 1H), 11.2 (s, 1H), 8.86 (s, 1H), 8.10 (s, 1H), 7.70 (m, 3H), 7.46 (m, 3H), 7.21 (d, 1H), 6.49 (s, 1H), M.P. 178-189° C.; LC-MS: 349 (MH+); HPLC RT 4.05 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06492383B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-a3300f3e785845cda5d817abcf43ee56 |
| Source note | uspto-grants-2002_12 |