3-(Trifluoromethyl)phenylboronic acid → HCID 86758652, compound

HRID 2297763Notes

Reaction equation

HRID 2297763 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[C:5](B(O)O)[CH:6]=[CH:7][CH:8]=1.Br[C:15]1[S:23][C:22]2[C:21]([NH:24]C3C=C4C(=CC=3)NC=C4)=[N:20][CH:19]=[N:18][C:17]=2[CH:16]=1>>[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[CH:5][C:6]([C:15]2[S:23][C:22]3[C:21]([NH2:24])=[N:20][CH:19]=[N:18][C:17]=3[CH:16]=2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 27343883-(Trifluoromethyl)phenylboronic acidHCID 18383051(6-Bromo-thieno[3,2-d]pyrimidin-4-yl)-(1H-indol-5-yl)-amine

Product 1

HCID 86758652HCID 86758652, compound

Procedure

The title compound was prepared from 3-trifluoromethylbenzeneboronic acid and (6-bromo-thieno[3,2-d]pyrimidin-4-yl)-(1H-indol-5-yl)-amine by a procedure analogous to example 2. M.P. 181-194° C.; LC-MS: 411 (MH+); HPLC RT: 4.88 minutes.

Sources & evidence

ORD record
ord-34e18695ee40403c81f91105c4e706d9
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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