Boronic acid, (4-ethylphenyl)- → [6-(4-Ethyl-phenyl)-thieno[3,2-d]pyrimidin-4-yl]-(1H-indol-5-yl)-amine

HRID 2297764Notes

Reaction equation

HRID 2297764 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6](B(O)O)=[CH:5][CH:4]=1)[CH3:2].Br[C:13]1[S:21][C:20]2[C:19]([NH:22][C:23]3[CH:24]=[C:25]4[C:29](=[CH:30][CH:31]=3)[NH:28][CH:27]=[CH:26]4)=[N:18][CH:17]=[N:16][C:15]=2[CH:14]=1>>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:13]2[S:21][C:20]3[C:19]([NH:22][C:23]4[CH:24]=[C:25]5[C:29](=[CH:30][CH:31]=4)[NH:28][CH:27]=[CH:26]5)=[N:18][CH:17]=[N:16][C:15]=3[CH:14]=2)=[CH:5][CH:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 2734352Boronic acid, (4-ethylphenyl)-HCID 18383051(6-Bromo-thieno[3,2-d]pyrimidin-4-yl)-(1H-indol-5-yl)-amine

Product 1

HCID 18382954[6-(4-Ethyl-phenyl)-thieno[3,2-d]pyrimidin-4-yl]-(1H-indol-5-yl)-amine

Procedure

The title compound was prepared from 4-ethylbenzeneboronic acid and (6-bromo-thieno[3,2-d]pyrimidin-4-yl)-(1H-indol-5-yl)-amine by a procedure analogous to example 2. M.P. 171-182° C.; LC-MS: 371 (MH+); HPLC RT: 5.13 minutes.

Sources & evidence

ORD record
ord-ba610377d71b4ca1a10a26e2b969971a
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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