3,4-Dimethoxyphenylboronic acid → [6-(3,4-Dimethoxy-phenyl)-thieno[3,2-d]pyrimidin-4-yl]-(1H-indol-5-yl)-amine

HRID 2297766Notes

Reaction equation

HRID 2297766 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5](B(O)O)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].Br[C:15]1[S:23][C:22]2[C:21]([NH:24][C:25]3[CH:26]=[C:27]4[C:31](=[CH:32][CH:33]=3)[NH:30][CH:29]=[CH:28]4)=[N:20][CH:19]=[N:18][C:17]=2[CH:16]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:15]2[S:23][C:22]3[C:21]([NH:24][C:25]4[CH:26]=[C:27]5[C:31](=[CH:32][CH:33]=4)[NH:30][CH:29]=[CH:28]5)=[N:20][CH:19]=[N:18][C:17]=3[CH:16]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

3

Reactant 2

HCID 27347023,4-Dimethoxyphenylboronic acidHCID 18383051(6-Bromo-thieno[3,2-d]pyrimidin-4-yl)-(1H-indol-5-yl)-amine

Product 1

HCID 18382842[6-(3,4-Dimethoxy-phenyl)-thieno[3,2-d]pyrimidin-4-yl]-(1H-indol-5-yl)-amine

Procedure

The title compound was prepared from 3,4-dimethoxybenzeneboronic acid and (6-bromo-thieno[3,2-d]pyrimidin-4-yl)-(1H-indol-5-yl)-amine by a procedure analogous to example 2. M.P. 171-178° C.; LC-MS: 403 (MH+); HPLC RT: 4.11 minutes.

Sources & evidence

ORD record
ord-d07e1ac106c84536b844a64f6313878e
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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