1-(2-Furoyl)piperazine → HCID 18383039, compound

HRID 2297791Notes

Reaction equation

HRID 2297791 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=[O:7].[NH:14]1[C:22]2[C:17](=[CH:18][C:19]([NH:23][C:24]3[C:25]4[S:32][C:31]([C:33]5[CH:40]=[CH:39][C:36]([CH:37]=O)=[CH:35][CH:34]=5)=[CH:30][C:26]=4[N:27]=[CH:28][N:29]=3)=[CH:20][CH:21]=2)[CH:16]=[CH:15]1>CS(C)=O>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([N:8]1[CH2:9][CH2:10][N:11]([CH2:37][C:36]2[CH:35]=[CH:34][C:33]([C:31]3[S:32][C:25]4[C:24]([NH:23][C:19]5[CH:18]=[C:17]6[C:22](=[CH:21][CH:20]=5)[NH:14][CH:15]=[CH:16]6)=[N:29][CH:28]=[N:27][C:26]=4[CH:30]=3)=[CH:40][CH:39]=2)[CH2:12][CH2:13]1)=[O:7]

Participants

4

Reactant 2

HCID 5502061-(2-Furoyl)piperazineHCID 183827594-(4-(1H-indol-5-ylamino)-thieno[3,2-d]pyrimidin-6-yl]-benzaldehyde

Product 1

HCID 18383039HCID 18383039, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

The title compound was prepared furan-2-yl-piperazin-1-yl-methanone and 4-[4-(1H-indol-5-ylamino)-thieno[3,2-d]pyrimidin-6-yl]-benzaldehyde by a procedure analogous to example 17. 1H NMR (400 MHz, DMSO) d; M. P. 167-174° C.; LC-MS: 535 (MH+); HPLC RT: 5.24 minutes.

Sources & evidence

ORD record
ord-81ff67f4b6a5472ab7c7d5e6aa01a5a6
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

Loading…