4-Fluorophenylboronic acid → [2-(4-Fluoro-phenyl)-thieno[3,2-b]pyridin-7-yl]-(1H-indol-5-yl)-amine

HRID 2297800Notes

Reaction equation

HRID 2297800 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5](B(O)O)=[CH:4][CH:3]=1.Br[C:12]1[S:20][C:19]2[C:14](=[N:15][CH:16]=[CH:17][C:18]=2[NH:21][C:22]2[CH:23]=[C:24]3[C:28](=[CH:29][CH:30]=2)[NH:27][CH:26]=[CH:25]3)[CH:13]=1>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:12]2[S:20][C:19]3[C:14](=[N:15][CH:16]=[CH:17][C:18]=3[NH:21][C:22]3[CH:23]=[C:24]4[C:28](=[CH:29][CH:30]=3)[NH:27][CH:26]=[CH:25]4)[CH:13]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 18382766(2-bromo-thieno[3,2-b]pyridin-7-yl)-(1H-indol-5-yl)-amine

Product 1

HCID 9906850[2-(4-Fluoro-phenyl)-thieno[3,2-b]pyridin-7-yl]-(1H-indol-5-yl)-amine

Procedure

The title compound was prepared from 4-fluorobenzeneboronic acid and (2-bromo-thieno[3,2-b]pyridin-7-yl)-(1H-indol-5-yl)-amine by a procedure analogous to example 17. 1H NMR (400 MHz, DMSO) d 11.4 (s, 1H), 10.7 (s, 1H), 8.28 (d, 1H), 7.50 (m, 9H), 7.05 (d, 1H), 6.49 (s, 1H); LC-MS: 360 (MH+); HPLC RT: 5.40 minutes.

Sources & evidence

ORD record
ord-7e383ab196ab4d6eb63819a6886b3370
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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