Diglycolamine → 2-(2-{4-[7-(1H-Indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-benzylamino}-ethoxy)-ethanol

HRID 2297801Notes

Reaction equation

HRID 2297801 reaction equation
[NH2:1][CH2:2][CH2:3][O:4][CH2:5][CH2:6][OH:7].[NH:8]1[C:16]2[C:11](=[CH:12][C:13]([NH:17][C:18]3[CH:23]=[CH:22][N:21]=[C:20]4[CH:24]=[C:25]([C:27]5[CH:34]=[CH:33][C:30]([CH:31]=O)=[CH:29][CH:28]=5)[S:26][C:19]=34)=[CH:14][CH:15]=2)[CH:10]=[CH:9]1>>[NH:8]1[C:16]2[C:11](=[CH:12][C:13]([NH:17][C:18]3[CH:23]=[CH:22][N:21]=[C:20]4[CH:24]=[C:25]([C:27]5[CH:34]=[CH:33][C:30]([CH2:31][NH:1][CH2:2][CH2:3][O:4][CH2:5][CH2:6][OH:7])=[CH:29][CH:28]=5)[S:26][C:19]=34)=[CH:14][CH:15]=2)[CH:10]=[CH:9]1

Participants

3

Reactant 2

HCID 13578DiglycolamineHCID 183827434-[7-(1H-Indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-benzaldehyde

Product 1

HCID 183828982-(2-{4-[7-(1H-Indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-benzylamino}-ethoxy)-ethanol

Procedure

The title compound was prepared from 2-(2-amino-ethoxy)-ethanol and 4-[7-(1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-benzaldehyde by a procedure analogous to example 17. LC-MS: 459 (MH+); HPLC RT: 3.48 minutes.

Sources & evidence

ORD record
ord-9893581e65704f90ac827aefbae97ae3
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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