Diethylamino-propanol → HCID 15400853, compound

HRID 2297812Notes

Reaction equation

C1(S([N:10]2[C:18]3[C:13](=[CH:14][C:15]([NH:19][C:20]4[C:21]5[S:28][C:27]([C:29]6[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=6)=[CH:26][C:22]=5[N:23]=[CH:24][N:25]=4)=[CH:16][CH:17]=3)[CH:12]=[CH:11]2)(=O)=O)C=CC=CC=1.[CH2:35]([N:37]([CH:40](O)[CH2:41][CH3:42])[CH2:38][CH3:39])[CH3:36]>>[CH2:35]([N:37]([CH2:38][CH3:39])[CH2:40][CH2:41][CH2:42][N:10]1[C:18]2[C:13](=[CH:14][C:15]([NH:19][C:20]3[C:21]4[S:28][C:27]([C:29]5[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=5)=[CH:26][C:22]=4[N:23]=[CH:24][N:25]=3)=[CH:16][CH:17]=2)[CH:12]=[CH:11]1)[CH3:36]

Participants

Reactant 2

HCID 5256659Diethylamino-propanol

HCID 11102921HCID 11102921, compound

Product 1

HCID 15400853HCID 15400853, compound

Procedure

The title compound was prepared from [1-benzenesulfonyl-1H-indol-5-yl]-(6-phenyl-thieno[3,2-d]pyrimidin-4-yl )-amine (246 mg, 1.00 mmol) and diethylamino-propanol (120 mg, 0.939 mmol) by a procedure analogous to example 69. RP18-HPLC RT: 4.55 minutes; API MS: 455.63 (M+1) MP: 178-180° C.

Sources & evidence

ORD record: ord-f9ac2ef0d4c64b7bb41777965c99991a
Source dataset: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06492383B1

Reaction notes

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