Indole-3-Carboxaldehyde → HCID 18382737, compound

HRID 2297816Notes

Reaction equation

HRID 2297816 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH:10]=O)=[CH:2]1.[C:12]1([C:18]2[S:26][C:25]3[C:24]([NH:27][C:28]4[CH:33]=[CH:32][C:31]([NH2:34])=[CH:30][CH:29]=4)=[N:23][CH:22]=[N:21][C:20]=3[CH:19]=2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([CH2:10][NH:34][C:31]2[CH:30]=[CH:29][C:28]([NH:27][C:24]3[C:25]4[S:26][C:18]([C:12]5[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=5)=[CH:19][C:20]=4[N:21]=[CH:22][N:23]=3)=[CH:33][CH:32]=2)=[CH:2]1

Participants

3

Reactant 2

HCID 10256Indole-3-CarboxaldehydeHCID 18383034HCID 18383034, compound

Product 1

HCID 18382737HCID 18382737, compound

Procedure

The title compound was prepared from 1H-indole-3-carbaldehyde(12 mg, 0.079 mmol) and N-(6-Phenyl-thieno[3,2-d]pyrimidin-4-yl)-benzene-1,4-diamine (150 mg, 0.471 mmol) by a procedure analogous to example 73. RP18-HPLC RT: 6.932 minutes; API MS: 448.20 (M+1) MP: 259-261° C.

Sources & evidence

ORD record
ord-f5a66b1cf0684babb81189908b558325
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

Loading…