2-Methoxyphenylboronic acid → HCID 18382955, compound

HRID 2297818Notes

Reaction equation

HRID 2297818 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1B(O)O.Br[C:13]1[S:21][C:20]2[C:19]([NH:22][C:23]3[CH:28]=[CH:27][C:26]([NH:29][C:30]4[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[CH:32][CH:31]=4)=[CH:25][CH:24]=3)=[N:18][CH:17]=[N:16][C:15]=2[CH:14]=1>>[CH3:37][O:36][C:33]1[CH:34]=[CH:35][C:30]([NH:29][C:26]2[CH:27]=[CH:28][C:23]([NH:22][C:19]3[C:20]4[S:21][C:13]([C:6]5[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=5)=[CH:14][C:15]=4[N:16]=[CH:17][N:18]=3)=[CH:24][CH:25]=2)=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 27339582-Methoxyphenylboronic acidHCID 18382822HCID 18382822, compound

Product 1

HCID 18382955HCID 18382955, compound

Procedure

The title compound was prepared from 2-methoxybenzeneboronic acid and N-(6-bromo-thieno[3,2-d]pyrimidin-4-yl)-N′-(4-methoxy-phenyl)-benzene-1,4-diamine by a procedure analogous to example 2. M.P. 159-169° C.; LC-MS: 454.31 (MH+); HPLC RT: 7.003 minutes.

Sources & evidence

ORD record
ord-b619dc818d5f46fb92719db60ebac412
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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