2-Thiopheneboronic acid → HCID 18383082, compound

HRID 2297819Notes

Reaction equation

HRID 2297819 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1B(O)O.Br[C:10]1[S:18][C:17]2[C:16]([NH:19][C:20]3[CH:25]=[CH:24][C:23]([NH:26][C:27]4[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=4)=[CH:22][CH:21]=3)=[N:15][CH:14]=[N:13][C:12]=2[CH:11]=1>>[CH3:34][O:33][C:30]1[CH:31]=[CH:32][C:27]([NH:26][C:23]2[CH:24]=[CH:25][C:20]([NH:19][C:16]3[C:17]4[S:18][C:10]([C:2]5[S:1][CH:5]=[CH:4][CH:3]=5)=[CH:11][C:12]=4[N:13]=[CH:14][N:15]=3)=[CH:21][CH:22]=2)=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 27339602-Thiopheneboronic acidHCID 18382822HCID 18382822, compound

Product 1

HCID 18383082HCID 18383082, compound

Procedure

The title compound was prepared from 2-thiophene boronic acid and N-(6-bromo-thieno[3,2-d]pyrimidin-4-yl)-N′-(4-methoxy-phenyl)-benzene-1,4-diamine by a procedure analogous to example 2. M.P. 231-40° C. ; LC-MS: 431 (MH+); HPLC RT: 6.740 minutes.

Sources & evidence

ORD record
ord-a2b6082519cb4f0d8ba2b4f2ea470474
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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