Furan-3-boronic acid → HCID 18382869, compound

HRID 2297834Notes

Reaction equation

HRID 2297834 reaction equation
[O:1]1[CH:5]=[CH:4][C:3](B(O)O)=[CH:2]1.Br[C:10]1[S:18][C:17]2[C:12](=[N:13][CH:14]=[CH:15][C:16]=2[NH:19][C:20]2[CH:21]=[C:22]3[C:26](=[CH:27][CH:28]=2)[NH:25][C:24]([CH3:29])=[CH:23]3)[CH:11]=1>>[O:1]1[CH:5]=[CH:4][C:3]([C:10]2[S:18][C:17]3[C:12](=[N:13][CH:14]=[CH:15][C:16]=3[NH:19][C:20]3[CH:21]=[C:22]4[C:26](=[CH:27][CH:28]=3)[NH:25][C:24]([CH3:29])=[CH:23]4)[CH:11]=2)=[CH:2]1

Participants

3

Reactant 2

HCID 2734358Furan-3-boronic acidHCID 183828502-Bromo-N-(2-methyl-1H-indol-5-yl)thieno[3,2-b]pyridin-7-amine

Product 1

HCID 18382869HCID 18382869, compound

Procedure

The title compound was prepared from 3-furanboronic acid and (2-bromo-thieno[3,2-b]pyridin-7-yl)-(2-methyl-1H-indol-5-yl)-amine by the procedure analogous to Example 2 above. 1H NMR (400 MHz, CD3OD) δ8.02 (d, 1H), 7.91 (s, 1H), 7.53 (m, 1H), 7.35 (s, 1H), 7.31 (d, 1H), 7.27 (d, 1H), 6.94 (dd, 1H), 6.77 (m, 1H), 6.54 (d, 1H), 6.10 (s, 1H), 2.40 (s, 3H), RP18-HPLC RT: 5.39 minutes; API MS: 346 (M+1).

Sources & evidence

ORD record
ord-92d9862b690f40848ba1a3cd7026d55f
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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