5-Amino-2-methylindole → HCID 18382839, compound

HRID 2297835Notes

Reaction equation

HRID 2297835 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH2:11])=[CH:6][CH:5]=2.Cl[C:13]1[CH:18]=[CH:17][N:16]=[C:15]2[CH:19]=[C:20]([C:22]3[S:26][C:25]([O:27][CH2:28][CH3:29])=[N:24][CH:23]=3)[S:21][C:14]=12>>[CH2:28]([O:27][C:25]1[S:26][C:22]([C:20]2[S:21][C:14]3[C:15](=[N:16][CH:17]=[CH:18][C:13]=3[NH:11][C:7]3[CH:8]=[C:9]4[C:4](=[CH:5][CH:6]=3)[NH:3][C:2]([CH3:1])=[CH:10]4)[CH:19]=2)=[CH:23][N:24]=1)[CH3:29]

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 18382940HCID 18382940, compound

Product 1

HCID 18382839HCID 18382839, compound

Procedure

The title compound was prepared from 2-methyl-5-aminoindole and 7-chloro-2-(2-ethoxy-thiazol-5-yl)-thieno[3,2-b]pyridine by the procedure analogous to example 148(c) above. 1H NMR (400 MHz, CD3OD) δ10.95 (s, 1H), 8.62 (s, 1H), 8.23 (d, 1H), 7.52 (s, 1H), 7.45 (s, 1H), 7.33 (m, 2H), 6.88 (d, 1H), 6.52 (d, 1H), 6.08 (s, 1H), 4.44 (q, 2H), 2.46 (s, 3H), 1.35 (t, 3H); RP18-HPLC RT: 5.83 minutes; API MS: 407 (M+1).

Sources & evidence

ORD record
ord-d2b076014b174f9ea28d626109b8c36d
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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