5-Amino-2-methylindole → HCID 18382914, compound

HRID 2297836Notes

Reaction equation

HRID 2297836 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH2:11])=[CH:6][CH:5]=2.Cl[C:13]1[CH:18]=[CH:17][N:16]=[C:15]2[CH:19]=[C:20]([C:22]3[S:23][CH:24]=[C:25]([CH3:27])[N:26]=3)[S:21][C:14]=12>>[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH:11][C:13]1[CH:18]=[CH:17][N:16]=[C:15]3[CH:19]=[C:20]([C:22]4[S:23][CH:24]=[C:25]([CH3:27])[N:26]=4)[S:21][C:14]=13)=[CH:6][CH:5]=2

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 18382933HCID 18382933, compound

Product 1

HCID 18382914HCID 18382914, compound

Procedure

The title compound was prepared from 2-methyl-5-aminoindole and 7-chloro-2-(4-methyl-thiazol-2-yl)-thieno[3,2-b]pyridine by the procedure analogous to example 148(c) above. 1H NMR (400 MHz, CD3OD) δ8.11 (d, 1H), 7.73 (s, 1H), 7.34 (s, 1H), 7.25 (d, 1H), 7.20 (s, 1H), 6.97 (d, 1H), 6.62 (d, 1H), 6.12 (s, 1H), 2.43 (s, 3H), 2.42 (s, 3H), RP18-HPLC RT: 5.41 minutes; API MS: 377 (M+1).

Sources & evidence

ORD record
ord-e45f064a2e5041719c383969b1b0de29
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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