5-Amino-2-methylindole → HCID 18382880, compound

HRID 2297837Notes

Reaction equation

HRID 2297837 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH2:11])=[CH:6][CH:5]=2.Cl[C:13]1[CH:18]=[CH:17][N:16]=[C:15]2[CH:19]=[C:20]([C:22]3[O:23][C:24]4[CH:30]=[CH:29][CH:28]=[CH:27][C:25]=4[N:26]=3)[S:21][C:14]=12>>[O:23]1[C:24]2[CH:30]=[CH:29][CH:28]=[CH:27][C:25]=2[N:26]=[C:22]1[C:20]1[S:21][C:14]2[C:15](=[N:16][CH:17]=[CH:18][C:13]=2[NH:11][C:7]2[CH:8]=[C:9]3[C:4](=[CH:5][CH:6]=2)[NH:3][C:2]([CH3:1])=[CH:10]3)[CH:19]=1

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 18382780HCID 18382780, compound

Product 1

HCID 18382880HCID 18382880, compound

Procedure

The title compound was prepared from 2-methyl-5-aminoindole and 2-(7-chloro-thieno[3,2-b]pyridin-2-yl)-benzooxazole by the procedure analogous to example 148(c) above. 1H NMR (400 MHz, CD3OD) δ8.18 (d, 1H), 8.10 (s, 1H), 7.70 (m, 2H), 7.40 (m, 4H), 6.98 (d, 1H), 6.68 (d, 1H), 6.14 (s, 1H), 2.43 (s, 3H); RP18-HPLC RT: 6.13 minutes; API MS 397 (M+1).

Sources & evidence

ORD record
ord-7cee45a7522648b2a40cfc5cd70ee071
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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