4-Methylthiophene-2-boronic acid → HCID 18382884, compound

HRID 2297838Notes

Reaction equation

HRID 2297838 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4](B(O)O)[S:5][CH:6]=1.Br[C:11]1[S:19][C:18]2[C:13](=[N:14][CH:15]=[CH:16][C:17]=2[NH:20][C:21]2[CH:22]=[C:23]3[C:27](=[CH:28][CH:29]=2)[NH:26][C:25]([CH3:30])=[CH:24]3)[CH:12]=1>>[CH3:30][C:25]1[NH:26][C:27]2[C:23]([CH:24]=1)=[CH:22][C:21]([NH:20][C:17]1[CH:16]=[CH:15][N:14]=[C:13]3[CH:12]=[C:11]([C:4]4[S:5][CH:6]=[C:2]([CH3:1])[CH:3]=4)[S:19][C:18]=13)=[CH:29][CH:28]=2

Participants

3

Reactant 2

HCID 27343734-Methylthiophene-2-boronic acidHCID 183828502-Bromo-N-(2-methyl-1H-indol-5-yl)thieno[3,2-b]pyridin-7-amine

Product 1

HCID 18382884HCID 18382884, compound

Procedure

The title compound was prepared from 4-methyl-2-thiopheneboronic acid and (2-bromothieno[3,2-b]pyridin-7-yl)-(2-methyl-1H-indol-5-yl)-amine by the procedure analogous to example 2 above. 1H NMR (400 MHz, CD3OD) δ8.00 (d, 1H), 7.25 (m, 3H), 7.10 (s, 1H), 6.95 (s, 1H), 6.94 (dd, 1H), 6.52 (d, 1H), 6.08 (s, 1H), 2.39 (s, 3H), 2.18 (s, 3H); RP18-HPLC RT: 6.41 minutes; API MS: 376 (M+1).

Sources & evidence

ORD record
ord-2dc87ec0290a43d4a9e33663fe57206d
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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