(2H-1,3-benzodioxol-5-yl)boronic acid → HCID 18382878, compound

HRID 2297839Notes

Reaction equation

HRID 2297839 reaction equation
[O:1]1[C:5]2[CH:6]=[CH:7][C:8](B(O)O)=[CH:9][C:4]=2[O:3][CH2:2]1.Br[C:14]1[S:22][C:21]2[C:16](=[N:17][CH:18]=[CH:19][C:20]=2[NH:23][C:24]2[CH:25]=[C:26]3[C:30](=[CH:31][CH:32]=2)[NH:29][C:28]([CH3:33])=[CH:27]3)[CH:15]=1>>[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:14]3[S:22][C:21]4[C:16](=[N:17][CH:18]=[CH:19][C:20]=4[NH:23][C:24]4[CH:25]=[C:26]5[C:30](=[CH:31][CH:32]=4)[NH:29][C:28]([CH3:33])=[CH:27]5)[CH:15]=3)=[CH:9][C:4]=2[O:3][CH2:2]1

Participants

3

Reactant 2

HCID 2734371(2H-1,3-benzodioxol-5-yl)boronic acidHCID 183828502-Bromo-N-(2-methyl-1H-indol-5-yl)thieno[3,2-b]pyridin-7-amine

Product 1

HCID 18382878HCID 18382878, compound

Procedure

The title compound was prepared from 1,3-benzodioxole-5-boronic acid and (2-bromothieno[3,2-b]pyridin-7-yl)-(2-methyl-1H-indol-5-yl)-amine by the procedure analogous to example 2 above. 1H NMR (400 MHz, CD3OD) δ8.00 (d, 1H), 7.38 (s, 1H), 7.26 (m, 2H), 7.13 (m, 2H), 6.93 (d, 1H), 6.77 (d, 1H), 6.52 (d, 1H), 6.08 (s, 1h), 5.92 (s, 2H), 2.39 (s, 3H); RP18-HPLC RT: 6.09 minutes; API MS: 400 (M+1).

Sources & evidence

ORD record
ord-017aa673c8ab439193bc6dbc046adb51
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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