2-Thiopheneboronic acid → HCID 18382991, compound

HRID 2297840Notes

Reaction equation

HRID 2297840 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1B(O)O.Br[C:10]1[S:18][C:17]2[C:12](=[N:13][CH:14]=[CH:15][C:16]=2[NH:19][C:20]2[CH:21]=[C:22]3[C:26](=[CH:27][CH:28]=2)[NH:25][C:24]([CH3:29])=[CH:23]3)[CH:11]=1>>[CH3:29][C:24]1[NH:25][C:26]2[C:22]([CH:23]=1)=[CH:21][C:20]([NH:19][C:16]1[CH:15]=[CH:14][N:13]=[C:12]3[CH:11]=[C:10]([C:2]4[S:1][CH:5]=[CH:4][CH:3]=4)[S:18][C:17]=13)=[CH:28][CH:27]=2

Participants

3

Reactant 2

HCID 27339602-Thiopheneboronic acidHCID 183828502-Bromo-N-(2-methyl-1H-indol-5-yl)thieno[3,2-b]pyridin-7-amine

Product 1

HCID 18382991HCID 18382991, compound

Procedure

The title compound was prepared from 2-thiophene-boronic acid and (2-bromothieno[3,2-b]pyridin-7-yl)-(2-methyl-1H-indol-5-yl)-amine by the procedure analogous to example 2 above. 1H NMR (400 MHz, CD3OD) δ8.01 (d, 1H), 7.39 (d, 1H), 7.36 (s, 1H), 7.30 (s, 1H), 7.26 (d, 1H), 7.01 (dd, 1H), 6.94 (dd, 1H), 6.53 (d, 1H), 6.09 (s, 1H), 2.39 (s, 3H); RP18-HPLC RT: 5.78 minutes; API MS: 362 (M+1).

Sources & evidence

ORD record
ord-8ceb8ff572714143b7211ba67165c4f9
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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