1-(tert-Butoxycarbonyl)-2-pyrroleboronic Acid → HCID 69993817, compound

HRID 2297841Notes

Reaction equation

HRID 2297841 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH:12]=[CH:11][CH:10]=[C:9]1B(O)O)=[O:7])([CH3:4])([CH3:3])[CH3:2].Br[C:17]1[S:25][C:24]2[C:19](=[N:20][CH:21]=[CH:22][C:23]=2[NH:26][C:27]2[CH:28]=[C:29]3[C:33](=[CH:34][CH:35]=2)[NH:32][C:31]([CH3:36])=[CH:30]3)[CH:18]=1>>[C:1]([O:5][C:6]([N:8]1[CH:12]=[CH:11][CH:10]=[C:9]1[C:17]1[S:25][C:24]2[C:19](=[N:20][CH:21]=[CH:22][C:23]=2[NH:26][C:27]2[CH:28]=[C:29]3[C:33](=[CH:34][CH:35]=2)[NH:32][C:31]([CH3:36])=[CH:30]3)[CH:18]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27343211-(tert-Butoxycarbonyl)-2-pyrroleboronic AcidHCID 183828502-Bromo-N-(2-methyl-1H-indol-5-yl)thieno[3,2-b]pyridin-7-amine

Product 1

HCID 69993817HCID 69993817, compound

Procedure

The title compound was prepared from N-tert-butoxycarbonylpyrrole-2-boronic acid and (2-bromothieno[3,2-b]pyridin-7-yl)-(2-methyl-1H-indol-5-yl)-amine by the procedure analogous to example 2 above. 1H NMR (400 MHz, CD3OD) δ8.08 (d, 1H), 7.36 (m, 2H), 7.28, s, 1H), 7.27 (d, 1H), 6.94 (dd, 1H), 6.60 (d, 1H), 6.40 (m, 1H), 6.22 (dd, 1H), 6.10 (s, 1H), 2.40 (s, 3H), 1.90 (s, 9H); RP18-HPLC RT: 6.73 minutes; API MS: 445 (M+1).

Sources & evidence

ORD record
ord-0dec675b92b841f5833a7318a04e2e03
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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