5-Amino-2-methylindole → HCID 18382821, compound

HRID 2297843Notes

Reaction equation

HRID 2297843 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH2:11])=[CH:6][CH:5]=2.Cl[C:13]1[CH:18]=[CH:17][N:16]=[C:15]2[CH:19]=[C:20]([C:22]3[O:23][C:24]([C:27]4[CH:32]=[CH:31][C:30]([O:33][CH3:34])=[CH:29][CH:28]=4)=[CH:25][N:26]=3)[S:21][C:14]=12>>[CH3:34][O:33][C:30]1[CH:31]=[CH:32][C:27]([C:24]2[O:23][C:22]([C:20]3[S:21][C:14]4[C:15](=[N:16][CH:17]=[CH:18][C:13]=4[NH:11][C:7]4[CH:8]=[C:9]5[C:4](=[CH:5][CH:6]=4)[NH:3][C:2]([CH3:1])=[CH:10]5)[CH:19]=3)=[N:26][CH:25]=2)=[CH:28][CH:29]=1

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 18382992HCID 18382992, compound

Product 1

HCID 18382821HCID 18382821, compound

Procedure

The title compound was prepared from 2-methyl-5-aminoindole and 7-chloro-2-[5-(4-methoxy-phenyl)-oxazol-2-yl]-thieno[3,2-b]pyridine by the procedure analogous to example 148(c) above. 1H NMR (400 MHz, CD3OD) δ11.00 (s, 1H), 8.79 (s, 1H), 8.21 (d, 1H), 7.98 (s, 1H), 7.79 (m, 2H), 7.76 (s, 1H), 7.24 (m, 2H), 7.08 (s, 1H), 7.06 (s, 1H), 6.85 (d, 1H), 6.60 (d, 1H), 6.10 (s, 1H), 3.79 (s, 3H), 2.42 (s, 3H); RP18-HPLC RT: 6.55 minutes; API MS: 453 (M+1).

Sources & evidence

ORD record
ord-6bcce3a2afe44421a80f21f52f3ffeab
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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