5-Amino-2-methylindole → HCID 18383048, compound

HRID 2297845Notes

Reaction equation

HRID 2297845 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH2:11])=[CH:6][CH:5]=2.Cl[C:13]1[CH:18]=[CH:17][N:16]=[C:15]2[CH:19]=[C:20]([C:22]3[CH:23]=[N:24][C:25]([N:28]4[C:32]([CH3:33])=[CH:31][CH:30]=[C:29]4[CH3:34])=[N:26][CH:27]=3)[S:21][C:14]=12>>[CH3:34][C:29]1[N:28]([C:25]2[N:26]=[CH:27][C:22]([C:20]3[S:21][C:14]4[C:15](=[N:16][CH:17]=[CH:18][C:13]=4[NH:11][C:7]4[CH:8]=[C:9]5[C:4](=[CH:5][CH:6]=4)[NH:3][C:2]([CH3:1])=[CH:10]5)[CH:19]=3)=[CH:23][N:24]=2)[C:32]([CH3:33])=[CH:31][CH:30]=1

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 18383072HCID 18383072, compound

Product 1

HCID 18383048HCID 18383048, compound

Procedure

The title compound was prepared from 2-methyl-5-aminoindole and 7-chloro-2-[2-(2,5-dimethyl-pyrrol-1-yl)-pyrimidin-5-yl]-thieno[3,2-b]pyridine by the procedure analogous to example 148(c) above. 1H NMR (400 MHz, CD3OD) δ9.18 (s, 2H), 8.17 (d, 1h), 7.80 (s, 1H), 7.37 (s, 1H), 7.34 (d, 1H), 6.98 (d, 1H), 6.62 (d, 1H), 6.17 (s, 1H), 5.83 (s, 1H), 2.47 (s, 3H), 2.33 (s, 6H); RP18-HPLC RT: 6.81 minutes; API MS: 451 (M+1).

Sources & evidence

ORD record
ord-73e0f0eb7241437997db365de08ee29e
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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