5-Amino-2-methylindole → HCID 18382920, compound

HRID 2297848Notes

Reaction equation

HRID 2297848 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH2:11])=[CH:6][CH:5]=2.Cl[C:13]1[CH:18]=[CH:17][N:16]=[C:15]2[CH:19]=[C:20]([C:22]3[CH:23]=[N:24][C:25]([N:29]4[C:33]([CH3:34])=[CH:32][CH:31]=[C:30]4[CH3:35])=[C:26]([CH3:28])[CH:27]=3)[S:21][C:14]=12>>[CH3:34][C:33]1[N:29]([C:25]2[N:24]=[CH:23][C:22]([C:20]3[S:21][C:14]4[C:15](=[N:16][CH:17]=[CH:18][C:13]=4[NH:11][C:7]4[CH:8]=[C:9]5[C:4](=[CH:5][CH:6]=4)[NH:3][C:2]([CH3:1])=[CH:10]5)[CH:19]=3)=[CH:27][C:26]=2[CH3:28])[C:30]([CH3:35])=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 18383084HCID 18383084, compound

Product 1

HCID 18382920HCID 18382920, compound

Procedure

The title compound was prepared from 2-methyl-5-aminoindole and 7-chloro-2-[6-(2,5-dimethyl-pyrrol-1-yl)-5-methyl-pyridin-3-yl]-thieno[3,2-b]pyridine by the procedure analogous to example 148(c) above. 1H NMR (400 MHz, CD3OD) δ8.71 (s, 1H), 8.17 (s, 1H), 8.08 (d, 1H), 7.77 (s, 1H), 7.30 (m, 2H), 6.95 (d, 1H), 6.58 (d, 1H), 6.11 (s, 1H), 5.84 (s, 2H), 2.40 (s, 3H), 1.99 (s, 3H), 1.91 (s, 6H); RP18-HPLC RT: 6.67 minutes.

Sources & evidence

ORD record
ord-f887c715e71d4e34932e54da8be358f2
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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