5-Amino-2-methylindole → HCID 18382934, compound

HRID 2297849Notes

Reaction equation

HRID 2297849 reaction equation
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][C:7]([NH2:11])=[CH:6][CH:5]=2.Cl[C:13]1[CH:18]=[CH:17][N:16]=[C:15]2[CH:19]=[C:20]([C:22]3[S:23][C:24]([C:28]([OH:31])([CH3:30])[CH3:29])=[C:25]([CH3:27])[N:26]=3)[S:21][C:14]=12>>[CH3:27][C:25]1[N:26]=[C:22]([C:20]2[S:21][C:14]3[C:15](=[N:16][CH:17]=[CH:18][C:13]=3[NH:11][C:7]3[CH:8]=[C:9]4[C:4](=[CH:5][CH:6]=3)[NH:3][C:2]([CH3:1])=[CH:10]4)[CH:19]=2)[S:23][C:24]=1[C:28]([OH:31])([CH3:30])[CH3:29]

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 18382846HCID 18382846, compound

Product 1

HCID 18382934HCID 18382934, compound

Procedure

The title compound was prepared from 2-methyl-5-aminoindole and 2-[2-(7-chloro-thieno[3,2-b]pyridin-2-yl)-4-methyl-thiazol-5-yl]-propan-2-ol by the procedure analogous to example 148(c) above. 1H NMR (400 MHz, CD3OD) δ8.07 (t, 1H), 7.62 (d, 1H), 7.27 (m, 2H), 6.95 (m, 1H), 6.58 (t, 1H), 6.10 (d, 1H), 5.46 (d, 1H), 2.46 (s, 3H), 2.40 (s, 3H), 1.60 (s, 6H); RP18-HPLC RT: 5.17 minutes; API MS: 435 (M+1).

Sources & evidence

ORD record
ord-d5c5ebe8ef3741eb9e31d5d8fe716682
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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