5-Amino-2-methylindole → HCID 18382739, compound

HRID 2297853Notes

Reaction equation

HRID 2297853 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]=[C:9]([C:11]3[N:16]=[C:15]([C:17]([OH:20])([CH3:19])[CH3:18])[CH:14]=[CH:13][CH:12]=3)[S:10][C:3]=12.[CH3:21][C:22]1[NH:23][C:24]2[C:29]([CH:30]=1)=[CH:28][C:27]([NH2:31])=[CH:26][CH:25]=2>>[CH3:21][C:22]1[NH:23][C:24]2[C:29]([CH:30]=1)=[CH:28][C:27]([NH:31][C:2]1[CH:7]=[CH:6][N:5]=[C:4]3[CH:8]=[C:9]([C:11]4[N:16]=[C:15]([C:17]([OH:20])([CH3:19])[CH3:18])[CH:14]=[CH:13][CH:12]=4)[S:10][C:3]=13)=[CH:26][CH:25]=2

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 18382970HCID 18382970, compound

Product 1

HCID 18382739HCID 18382739, compound

Procedure

The title compound was prepared from 2-[6-(7-chloro-thieno[3,2-b]pyridin-2-yl)-pyridin-2-yl]-propan-2-ol and 2-methyl-5-aminoindole by the procedure analogous to example 148(c) above. 1H NMR (400 MHz, CD3OD) δ8.05 (d, 1H), 7.83 (s, 1H), 7.75 (m, 2H), 7.53 (d, 1H), 7.33 (s, 1H), 7.27 (d, 1H), 6.95 (d, 1H), 6.56 (d, 1H), 6.10 (s, 1H), 2.40 (s, 3H), 1.54 (s, 6H); RP18-HPLC RT: 5.05 minutes; API MS: 415 (M+1).

Sources & evidence

ORD record
ord-99a9ece0215848f38ac9c3192e86f36e
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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