HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-2-methylindole → {6-[7-(2-Methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-pyridin-2-yl}-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-2-methylindole | HCID 2733992 | — |
| Reactant | [6-(7-Chloro-thieno[3,2-b]pyridin-2-yl)-pyridin-2-yl]-methanol | HCID 18382959 | — |
| Product | {6-[7-(2-Methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-pyridin-2-yl}-methanol | HCID 18383092 | — |
Reaction Steps
The title compound was prepared from [6-(7-chloro-thieno[3,2-b]pyridin-2-yl)-pyridin-2-yl]-methanol and 2-methyl-5-aminoindole by the procedure analogous to example 148(c) above. 1H NMR (400 MHz, CD3OD) δ8.10 (d, 1H), 7.90 (s, 1H), 7.83 (m, 2H), 7.44 (m, 1H), 7.36 (s, 1H), 7.30 (d, 1H), 6.90 (d, 1H), 6.60 (d, 1H), 6.12 (s, 1H), 3.57 (s, 2H), 2.42 (s, 3H); RP18-HPLC RT: 4.59 minutes; API MS: 387 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06492383B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-a657d58e91164c6cb0015088456b3251 |
| Source note | uspto-grants-2002_12 |