5-Amino-2-methylindole → {6-[7-(2-Methyl-1H-indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-pyridin-2-yl}-(4-methyl-piperazin-1-yl)-methanone

Participants

Reaction Steps

The title compound was prepared from [6-(7-chloro-thieno[3,2-b]pyridin-2-yl)-pyridin-2-yl]-(4-methyl-piperazin-1-yl)-methanone and 2-methyl-5-aminoindole by the procedure analogous to example 148(c) above. 1H NMR (400 MHz, CD3OD) δ8.06 (d, 1H), 7.90 (m, 3H), 7.58 (d, 1H), 7.30 (m, 2H), 6.93 (d, 1H), 6.62 (d, 1H), 6.10 (s, 1H), 3.77 (m, 2H), 3.59 (m, 2H), 2.55 (m, 2H), 2.40 (m, 2H), 2.40 (s, 3H), 2.31 (s, 3H); RP18-HPLC RT: 3.92 minutes; API MS: 483 (M+1).

Provenance & Evidence