5-Amino-2-methylindole → HCID 18383091, compound

HRID 2297857Notes

Reaction equation

HRID 2297857 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]2[CH:8]=[C:9]([C:11]3[N:12]([CH2:16][O:17][CH3:18])[CH:13]=[CH:14][N:15]=3)[S:10][C:3]=12.[CH3:19][C:20]1[NH:21][C:22]2[C:27]([CH:28]=1)=[CH:26][C:25]([NH2:29])=[CH:24][CH:23]=2>>[CH3:18][O:17][CH2:16][N:12]1[CH:13]=[CH:14][N:15]=[C:11]1[C:9]1[S:10][C:3]2[C:4](=[N:5][CH:6]=[CH:7][C:2]=2[NH:29][C:25]2[CH:26]=[C:27]3[C:22](=[CH:23][CH:24]=2)[NH:21][C:20]([CH3:19])=[CH:28]3)[CH:8]=1

Participants

3

Reactant 2

HCID 27339925-Amino-2-methylindoleHCID 18382805HCID 18382805, compound

Product 1

HCID 18383091HCID 18383091, compound

Procedure

The title compound was prepared from 7-chloro-2-(1-methoxymethyl-1H-imidazol-2-yl)-thieno[3,2-b]pyridine and 2-methyl-5-aminoindole by the procedure analogous to example 148(c) above. 1H NMR (400 MHz, CD3OD) δ8.15 (d, 1H), 7.85 (s, 1H), 7.53 (s, 1H), 7.37 (m, 2H), 7.11 (s, 1H), 7.02 (d, 1H), 6.81 (d, 1H), 6.19 (s, 1H), 5.46 (s, 2H), 3.38 (s, 1H), 2.44 (s, 1H); RP18-HPLC RT: 4.38 minutes; API MS: 390 (M+1).

Sources & evidence

ORD record
ord-901c99d9d0474810994559667041b94e
Source dataset
uspto-grants-2002_12
Patent number
US06492383B1

Reaction notes

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