HCID 1133837, compound → HCID 178517003, compound

Participants

Reaction Conditions

Reaction Steps

To a test tube (20 mm by 150 mm) was added a magnetic stir bar, 8-[ethoxymethylidene]-6H-[1,3]thiazolo[5,4-e]indol-7-one (0.123 gram, 0.5 mmol), 4-amino-N-(4-pyridinylmethyl)benzenesulfonamide (0.132 gram, 0.5 mmol) and 95% ethanol (5 milliliters). The reaction mixture was sealed with a rubber septum (14/22) and vented with a 3-inch 18-gauge hypodermic needle. The reaction vessel was placed in an oil bath at room temperature with stirring, and the temperature of the oil bath was then raised to 78° C. and maintained at that temperature for approximately 24 hours. The reaction vessel was removed from the oil bath and allowed to cool until warm to the touch. The resulting precipitate was collected by suction filtration. The solid was washed with excess 95% ethanol and collected by suction filtration. The resultant solid was dried under vacuum for two hours at 40° C. The solid was allowed to cool to yield 52 mg (11%) of the title compound. MS (M+H)=464.

Provenance & Evidence