HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2297966Generated: October 30, 2026
Trifluoroacetic acid → d-Valine benzyl ester trifluoroacetic acid salt
https://huagongshe.com/reaction/2297966
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (R)-benzyl 2-((tert-butoxycarbonyl)amino)-3-methylbutanoate | HCID 11243734 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | d-Valine benzyl ester trifluoroacetic acid salt | HCID 69764497 | — |
Reaction Steps
N-Tert-butoxycarbonyl-D-valine benzyl ester (70.7 g, 0.23 mol) was dissolved in a mixture of trifluoroacetic acid and methylene chloride (150 mL in 1:4 ratio) and the reaction mixture was heated at 50-60° C. After 6 h, the reaction mixture was concentrated to give D-valine benzyl ester trifluoroacetic acid salt (156.8 g) as a viscous oil which was converted to the free amine just prior to use.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06492394B1 |
|---|
| Source dataset | uspto-grants-2002_12 |
|---|
| ORD ID | ord-ada56c6a23904ef2a227aa1ac2747bed |
|---|
| Source note | uspto-grants-2002_12 |
|---|
