HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Indole-5-Carboxylic Acid → methyl 1H-indole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Indole-5-Carboxylic Acid | HCID 74280 | — |
| Reactant | Trimethylsilyldiazomethane | HCID 167693 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | methyl 1H-indole-5-carboxylate | HCID 2737635 | — |
Reaction Steps
To a solution of 1H-indole-5-carboxylic acid (5 g, 31.0 mmol) in 70% methanol/methylene chloride (105 mL) at 0° C. was added 1M trimethylsilyldiazomethane in hexanes (46 mL, 46 mmol). After 45 min., the reaction mixture was concentrated to afford 1H-indole-5-carboxylic acid methyl ester (5.2 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06492394B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-6c01a48eefd44673b6e166e4cd00ce11 |
| Source note | uspto-grants-2002_12 |