Methanol → HCID 22267761, compound

Participants

Reaction Conditions

Reaction Steps

A solution of ethyl 5-cyclopropyl-1-(2-methylthiophenyl)-1H-pyrazole-4-carboxylate (0.456 g, 1.51 mmol) in methanol (6 mL) at 0° C. was treated with a solution of oxone (1.40 g, 2.27 mmol) in water (6 mL). The resulting slurry was was stirred at 23° C. for 8 h. The mixture was treated with additional oxone (0.46 g, 0.76 mmol), stirred for 14 h and partitioned between CH2Cl2 and water. The organic layer was washed with water, dried over MgSO4 and concentrated in vacuo to afford 0.504 g (100%) of the title compound.

Provenance & Evidence