HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 86758645, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Ethyl 5-bromo-2-chlorobenzoate | HCID 144749 | — |
| Reactant | Binap, (A+-)- | HCID 634876 | — |
| Reactant | tert-butyl N-(pyrrolidin-3-yl)carbamate | HCID 2757234 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 86758645 | HCID 86758645 | 35.7% |
Reaction Steps
Prepared as described in Example 5a) using 5-bromo-2-chloro-benzoic acid, ethyl ester (0.50 g), 3-pyrrolidinyl-carbamic acid 1,1-dimethylethyl ester (0.42 g), cesium carbonate (0.86 g), palladium (II) acetate (21 mg) and (R)-BINAP (88 mg) and toluene (3 ml) to afford the subtitle compound as an oil (0.25 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06492355B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-46355b0850bf4d3b9a3568ca2d85fcec |
| Source note | uspto-grants-2002_12 |