Potassium Carbonate → HCID 86758646, compound

Participants

Reaction Steps

A mixture 5-(bromomethyl)-2-chloro-N-(2-tricyclo[3.3.1.13,7]dec-1-ylethyl)-benzamide (Example 18a, 0.35 g), 1-tertbutyloxycarbonylpiperazine (0.213 g), potassium carbonate (0.20 g) and potassium iodide (10 mg) in acetone (5 ml) was heated at 60° C. for 2 h. The acetone was removed under vacuum, the residue taken into dichlorometane and the solid removed by filtration. The crude material was purified on a silica gel eluting with dichloromethane/ethanol (0-10% gradient) to afford the subtitle compound as a white foam (0.383 g).

Provenance & Evidence