HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium triacetoxyborohydride → HCID 57204187, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 2-Chloro-5-formyl-N-(tricyclo [3.3.1.13,7]dec-1-ylmethyl)-benzamide | HCID 12085346 | — |
| Reactant | 1,1-Dimethylethyl N-((4-aminocyclohexyl)methyl)carbamate | HCID 21882540 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | HCID 57204187 | HCID 57204187 | 52.8% |
Reaction Steps
Prepared according to the method described in Example 31b from 2-chloro-5-formyl-N-(tricyclo [3.3.1.13,7]dec-1-ylmethyl)-benzamide (0.30 g, Example 31a), [(4-aminocyclohexyl)methyl]-carbamic acid, 1,1-dimethylethyl ester (0.207 g, WO 97/32882), sodium triacetoxyborohydride (0.135 g) and 1,2-dichloroethane (10 ml). The residue was purified by chromatography over silica gel eluting with ethyl acetate: iso-hexane (1:1) then ethyl acetate: ethanol (9:1) to give the subtitle compound as a colourless oil (0.26 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06492355B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-92a1936245834318919221e5fccb12c2 |
| Source note | uspto-grants-2002_12 |