Hydrochloric Acid → 2-Chloro-5-(4-piperidinylidenemethyl)-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide, hydrochloride salt

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Reaction Steps

A solution of 4-[[4-chloro-3-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]phenyl]methylene]-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester (0.10 g, Example 50b) in methanol (3 ml) was treated with a 4N solution of hydrochloric acid in dioxane (1 ml) and stirred for 14 h at room temperature. The reaction mixture was concentrated under vacuum and the residue recrystallised from iso-propanol/ether to give the title compound as a white solid (0.071 g).

Provenance & Evidence