Potassium Iodide → HCID 18381502, compound

Participants

Reaction Steps

A mixture of 2-bromo-5-bromomethyl-N-(tricyclo[3.3.1.13,7]dec-1-ylmethyl)-benzamide (Example 65a, 5.0 g), 1-tertbutyloxycarbonylpiperazine (2.3 g), potassium carbonate (3.2 g), potassium iodide (0.30 g) and acetone (75 ml) was refluxed in the dark for 14 h. The mixture was concentrated in vacuo, partitioned between ethyl acetate and water, then washed with brine. The organic layer was dried over magnesium sulfate and concentrated in vacuo. Recrystallization from ethyl acetate:isohexane gave the subtitle compound as colourless solid (4.7 g).

Provenance & Evidence