HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 131723703, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-(Adamantan-1-yl)ethan-1-amine hydrochloride | HCID 2771138 | — |
| Reactant | HCID 53742797 | HCID 53742797 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 131723703 | HCID 131723703 | 43.2% |
Reaction Steps
Prepared as described in example 74 above using (+/−)-2-chloro-5-[3-[[(1,1-dimethylethoxy)carbonyl]amino]-1-pyrrolidinyl]-benzoic acid (0.090 g), 1,1′-carbonyldiimidazole (0.043 g), tricyclo[3.3.1.13,7]decane-1-ethanamine, hydrochloride salt (0.057 g), N,N-diisopropylethylamine (0.046 ml) and dimethylformamide (3 ml). This compound was treated with 4N hydrochloric acid in dioxane (0.5 ml) and methanol (5 ml) to yield the title compound (0.025 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06492355B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-5e3c9e4b3ee042d898588752e5c124fe |
| Source note | uspto-grants-2002_12 |