Hydrochloric Acid → HCID 131723704, Verbindung

HRID 2298106Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2298106
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([C:6]([CH:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)=[O:7])=[CH:4][C:3]=1[C:23]([NH:25][CH2:26][C:27]12[CH2:36][CH:31]3[CH2:32][CH:33]([CH2:35][CH:29]([CH2:30]3)[CH2:28]1)[CH2:34]2)=[O:24].Cl>CO.O1CCOCC1>[ClH:1].[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([C:6]([CH:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)=[O:7])=[CH:4][C:3]=1[C:23]([NH:25][CH2:26][C:27]12[CH2:28][CH:29]3[CH2:30][CH:31]([CH2:32][CH:33]([CH2:35]3)[CH2:34]1)[CH2:36]2)=[O:24]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 57148713HCID 57148713, Verbindung

Produkt 1

HCID 131723704HCID 131723704, VerbindungAusbeute 81,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 887MethanolLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A solution of 4-[4-chloro-3-[[(tricyclo[3.3.1.13,7]dec-1-ylmethyl)amino]carbonyl]benzoyl]-1-piperidinecarboxylic acid, 1,1-dimethylethyl ester (0.07 g, Example 76a) in methanol (3 ml) was treated with 4N hydrochloric acid solution in dioxane (1 ml). After 14 h the solvents were removed under reduced pressure and the residue was triturated with diethyl ether to give the title compound as a white powder (0.025 g).

Aufarbeitung

  1. customAfter 14 h the solvents were removed under reduced pressure
  2. customthe residue was triturated with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-cc5853a9f8af476ab7ca491ac61dca59
Quelldatensatz
uspto-grants-2002_12
Patentnummer
US06492355B1

Notizen zur Reaktion

Wird geladen…