Diisobutylaluminum hydride → HCID 18386363, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (4-(2-benzoyl-5-isopropyl-4-methoxy-phenoxy)-3,5-dibromo-phenyl)-acetic acid methyl ester (100 mg, 0.17 mmol) in THF under N2 atmosphere was added DIBAL (0.87 ml, 5 eq) dropwise at 0° C. The reaction was stirred at 0° C. for 15 minutes and allowed to reach room temperature and stirred for another 2 h. The mixture was poured into ice, and the aqueous phase extracted with EtOAc and the combined organic layers were dried over MgSO4 and concentrated. Purification on silica gave 2-(3,5-dibromo-4-(2-(hydroxy-phenyl-methyl)-5-isopropyl-4-methoxy-phenoxy)-phenyl)-ethanol as a solid (mg, %). 1H NMR (CD3COCD3): d

Provenance & Evidence