Phthalimide → HCID 18385306, compound

Participants

Reaction Steps

To a solution of the product from Example 1 (80 mg, 0.189 mmol) in dry THF (10 mL) was added phthalimide (42 mg, 0.28 mmol) and triphenylphosphine (74 mg, 0.28 mmol). The mixture was cooled on an ice bath and diethyl azodicarboxylate (44 μL, 0.28 mmol) was added. The reaction mixture was allowed to reach room temperature and was then stirred overnight. Concentration and silica gel chromatography (dichloromethane-methanol, 99:1/98:2/95:5) gave 73 mg (70%) of the sub-title compound.

Provenance & Evidence