1,3-Dibromopropane → HCID 53735845, compound

Participants

Reaction Conditions

Reaction Steps

In a flask was dissolved indole-3-carboxylic acid methyl ester (2.0 g, 11.4 mmole) and 1,3-dibromopropane (11.5 g, 57 mmol) in 15 mL of DMF. To this solution was added cesium carbonate (5.5 g, 17 mmol). The flask was sealed and the content was stirred at 40° C. overnight. The solution was then partitioned between ether and water. The ethereal phase was washed twice with water and once with brine and was finally evaporated. The residue was purified on silica (heptane-ethyl acetate 4:1), to give 2.2 g (75%) of the sub-title compound.

Provenance & Evidence