Potassium Cyanide → HCID 18385060, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the product from Example 18 (0.86 g, 1.77 mmol) in dry DMF (25 mL) was added potassium cyanide (0.18 g, 2.77 mmol) and the mixture was stirred and heated at 50° C. overnight under nitrogen. The solvent was evaporated, and the residue was distributed between ethyl acetate and water. The water phase was extracted twice with ethyl acetate, and the combined organic phases were washed with water and dried. After evaporation the crude product was chromatographed on silica gel (EtOAc) to yield 0.46 g (61%) of the title product.

Provenance & Evidence