HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Iodide → Tyrosine Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | HCID 54334627 | HCID 54334627 | — |
| Solvent | Methyl Ethyl Ketone | HCID 6569 | — |
| Product | Tyrosine Methyl Ester | HCID 70652 | — |
Reaction Steps
N-(Toluene-4-sulfonyl)-L-prolyl-O-[(1-tert-butoxycarbonyl)-piperidin-3-yl)methyl]-L-tyrosine methyl ester was prepared via O-alkylation of N-(toluene-4-sulfonyl)-L-prolyl-L-tyrosine methyl ester with N-Boc-3-piperidinemethyl tosylate in refluxing 2-butanone in the presence of potassium carbonate and sodium iodide to provide a solid, mp=60-62° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06492421B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-c98bd1b439a64588b72bb41151ed72d6 |
| Source note | uspto-grants-2002_12 |