Thiophene-3-boronic acid → 2,2-dimethyl-5-{4-(methylsulfonyl)phenyl}-4-(3-thienyl)-3(2H)-furanone

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Reaction Steps

200 mg of 4-bromo-2,2-dimethyl-5-{4-(methylsulfonyl)phenyl}-3(2H)-furanone was coupled with 100 mg of thiophene-3-boronic acid according to a procedure similar to the synthetic procedure in Example 2 to yield 10 mg of 2,2-dimethyl-5-{4-(methylsulfonyl)phenyl}-4-(3-thienyl)-3(2H)-furanone as a solid. NMR: δ1.56 (s, 6H), 3.09 (s, 3H), 6.92-6.93 (m, 1H), 7.32-7.35 (m, 1H), 7.51-7.52 (m, 1H), 7.90-7.93 (m, 2H), 7.97-8.00 (m, 2H).

Provenance & Evidence