HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trityl chloride → 4-Bromo-1-trityl-1H-pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trityl chloride | HCID 6456 | — |
| Reactant | 4-Bromopyrazole | HCID 16375 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 4-Bromo-1-trityl-1H-pyrazole | HCID 10834188 | 99.7% |
Reaction Steps
A mixture of 0.5 g of 4-bromopyrazole and 1.43 g of tritylchloride in 30 ml of pyridine was stirred at reflux for 18 hours. The pyridine was removed in vacuo and the resulting residue was purified by silica column chromatography (ethylacetate/hexane=1:1) to yield 1.32 g of 4-bromo-1-N-tritylpyrazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06492416B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-09fa739e7f3d4025bd0055bfe2fedb08 |
| Source note | uspto-grants-2002_12 |