3-Fluoro-4-methoxyphenylboronic acid → HCID 18385612, compound

Participants

Reaction Steps

100 mg of 5-{4-(aminosulfonyl)phenyl}-2-ethyl-4-iodo-2-methyl-3(2H)-furanone was reacted with 80 mg of 3-fluoro-4-methoxybenzeneboronic acid by following a procedure similar to the procedure for the Step 2 of Example 35 to give 25 mg of 5-{4-(aminosulfonyl)phenyl}-2-ethyl-4-(3-fluoro-4-methoxyphenyl)-2-methyl-3(2H)-furanone as a solid. mp: 113-114° C. NMR: δ0.94 (t, J=7.5 Hz, 3H), 1.53 (s, 3H), 1.95 (q, J=7.5 Hz, 2H), 3.91 (s, 3H), 4.96 (br s, 2H), 6.99 (m, 3H), 7.80 (d, J=8.4 Hz, 2H), 7.93 (d, J=8.7 Hz, 2H). IR (cm−1): 3259, 1689, 1608, 1517, 1270, 1159. MS (FAB): 406 (m+1).

Provenance & Evidence