Bromine → HCID 18385950, compound

Participants

Reaction Steps

50 mg of 2-{4-(methylsulfonyl)phenyl}-1-oxa-spiro[4,5]dec-2-en-4-one was reacted with bromine (0.5 ml) in the presence of 0.1 ml acetic acid to yield 68 mg of 3-bromo-2-{4-(methylsulfonyl)phenyl}-1-oxa-spiro[4,5]dec-2-en-4-one by following a procedure similar to the procedure in Step 5 of Example 53. mp: 163-164° C. NMR: δ1.79 (m, 10H), 3.11 (s, 3H), 8.10 (d, J=8.1 Hz, 2H), 8.40 (d, J=8.1 Hz, 2H). IR (cm−1): 2936, 1709, 1583, 1316, 1149, 912, 744.

Provenance & Evidence