Dichloromethane → HCID 18386111, compound

Participants

Reaction Steps

50 mg of 2,2-dimethyl-5-{4-(methylsulfonyl)phenyl}-4-{4-(methylthio)-phenyl}-3(2H)-furanone (Example 72) in 10 ml dichloromethane and 2 ml methanol was stirred with 300 mg of OXONE at room temperature for 4 hours. The insoluble material was filtered off and the filtrate was washed with aqueous sodium bicarbonate. The organic layer was then concentrated under reduced pressure and was purified by column chromatography (ethylacetate) to give 45 mg of 2,2-dimethyl-4,5-di{4-(methylsulfonyl)phenyl}-3(2H)-furanone. mp: 245-257° C. NMR: δ1.60 (s, 6H), 3.08 (s, 3H), 3.10 (s, 3H), 7.50-7.53 (m, 2H), 7.79-7.82 (m, 2H), 7.94-8.00 (m, 4H). IR (cm−1): 2931, 1698, 1510, 1387, 1258, 1150, 960, 846, 770.

Provenance & Evidence