1-Phenethylamine, (-)- → HCID 9848045, compound

Participants

Reaction Steps

A solution of 1-(2-methylsulfonylpyrimidin4-yl)-2-(3-trifluoromethylphenyl)-1H-imidazole4-carboxylic acid ethyl ester (4.5 g, 0.0102 mol) in (S)-α-methylbenzylamine (20 mL) was stirred at room temperature for 30 min. The reaction was partitioned between 300 mL ethyl acetate and 300 mL pH 4.5 citric acid solution (buffered with NaOH) and the ethyl acetate dried over anhydrous magnesium sulfate. Concentration of the ethyl acetate afforded 4.8 g of the title compound. A portion of this material was purified by reverse phase HPLC on C18 silica eluting with a gradient of 100% water to 30% water: 70% acetonitrile (both containing 0.1% trifluoroacetic acid.

Provenance & Evidence