HCID 21912453, compound → HCID 10224206, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-[4-(1-ethyl-propylamino)-6-methyl-2-(2,4,6-trimethyl-phenoxy)-pyridin-3-ylmethyl]-malonic acid dimethyl ester (22 mg, 0.048 mmol) and 2 ml of acetic acid and bubbled through HCl (g) was heated at 130° C. for 30 hours. The reaction was cooled and concentrated to dryness. The residue was quenched with water and extracted with ethyl acetate. The organic layer was dried and concentrated to give 7 mg of the title compound. 1H NMR (CDCl3) δ 6.89(s,2H), 6.59(s,1H), 4.4(m,1H), 3.72(s,3H), 3.6-3.8(m,1H), 3.4-3.6(m,1H), 3.1-3.2(dd,1 H), 2.31(s,3H), 2.28(s,3H), 2.06(s,6H), 1.8-2.2(m,4H), 0.92(t,6H) ppm.

Provenance & Evidence